Quercetin-POM (pivaloxymethyl) conjugates: Modulatory activity for P-glycoprotein-based multidrug resistance.

  title={Quercetin-POM (pivaloxymethyl) conjugates: Modulatory activity for P-glycoprotein-based multidrug resistance.},
  author={Mi Kyoung Kim and Kwang-Su Park and Hyunah Choo and Youhoon Chong},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  volume={22 7-8},
  • M. K. Kim, Kwang-Su Park, +1 author Y. Chong
  • Published 15 July 2015
  • Chemistry, Medicine
  • Phytomedicine : international journal of phytotherapy and phytopharmacology
BACKGROUND We previously demonstrated that the bioactivity of quercetin could be improved through conjugation with a hydrolysable pivaloxymethyl (POM) group. PURPOSE Present study aimed to evaluate MDR (multidrug resistance)-modulatory activity of the quercetin-POM conjugates. STUDY DESIGN/METHODS MDR-modulatory activity was determined by measuring cytotoxicity of various anticancer agents to MDR MES-SA/Dx5 cell lines upon combination with the quercetin-POM conjugates. RESULTS The… Expand
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