Quercetin, not caffeine, is a major neuroprotective component in coffee.

@article{Lee2016QuercetinNC,
  title={Quercetin, not caffeine, is a major neuroprotective component in coffee.},
  author={Moonhee Lee and E. G. McGeer P. L. McGeer and Patrick L. Mcgeer},
  journal={Neurobiology of aging},
  year={2016},
  volume={46},
  pages={113-23}
}
Epidemiologic studies indicate that coffee consumption reduces the risk of Parkinson's disease and Alzheimer's disease. To determine the factors involved, we examined the protective effects of coffee components. The test involved prevention of neurotoxicity to SH-SY5Y cells that was induced by lipopolysaccharide plus interferon-γ or interferon-γ released from activated microglia and astrocytes. We found that quercetin, flavones, chlorogenic acid, and caffeine protected SH-SY5Y cells from these… CONTINUE READING

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