Quercetin, but not its glycosidated conjugate rutin, inhibits azoxymethane-induced colorectal carcinogenesis in F344 rats.

@article{Dihal2006QuercetinBN,
  title={Quercetin, but not its glycosidated conjugate rutin, inhibits azoxymethane-induced colorectal carcinogenesis in F344 rats.},
  author={Ashwin A. Dihal and Vincent C. J. de Boer and Hester van der Woude and Chantal Tilburgs and Joost P. Bruijntjes and Gerrit M. Alink and Ivonne M. C. M. Rietjens and Ruud A. Woutersen and Rob H. Stierum},
  journal={The Journal of nutrition},
  year={2006},
  volume={136 11},
  pages={2862-7}
}
The effect of the flavonoid quercetin and its conjugate rutin was investigated on (biomarkers of) colorectal cancer (CRC). Male F344 rats (n = 42/group) were fed 0, 0.1, 1, or 10 g quercetin/kg diet or 40 g rutin/kg diet. Two wk after initial administration of experimental diets, rats were given 2 weekly subcutaneous injections with 15 mg/kg body wt azoxymethane (AOM). At wk 38 post-AOM, quercetin dose dependently (P < 0.05) decreased the tumor incidence, multiplicity, and size, whereas tumor… CONTINUE READING
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