Quercetin, an inhibitor of lactate transport and a hyperthermic sensitizer of HeLa cells.

  title={Quercetin, an inhibitor of lactate transport and a hyperthermic sensitizer of HeLa cells.},
  author={Jae Ho Kim and Sung Hoon Kim and Alan A. Alfieri and Charles W. Young},
  journal={Cancer research},
  volume={44 1},
Since cancer cells produce large amounts of lactate via aerobic glycolysis and since an acidic pH has been shown to selectively enhance the cytotoxic effects of hyperthermia, we are examining the influence of cell exposure to drugs which inhibit lactate transport and lower intracellular pH upon cytotoxic effects of hyperthermia. Quercetin, a bioflavonoid that produces lactate transport inhibition, was not cytotoxic up to 4 hr at 37 degrees (0.1 mM). When HeLa cells were exposed to quercetin at… CONTINUE READING
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