Quercetin, a Flavonoid Antioxidant, Ameliorated Procarbazine-Induced Oxidative Damage to Murine Tissues

@article{Olayinka2015QuercetinAF,
  title={Quercetin, a Flavonoid Antioxidant, Ameliorated Procarbazine-Induced Oxidative Damage to Murine Tissues},
  author={Ebenezer Tunde Olayinka and Ayokanmi Ore and Oluwatobi Adewumi Adeyemo and Olaniyi Solomon Ola and Olaoluwa Oluwaseun Olotu and Roseline Chinonye Echebiri},
  journal={Antioxidants},
  year={2015},
  volume={4},
  pages={304 - 321}
}
Procarbazine (PCZ) (indicated in Hodgkin’s disease), is an alkylating agent known to generate free radicals in vivo, while Quercetin (QCT) is a flavonoid antioxidant with proven free radical scavenging capacity. This study investigated the protective effects of QCT on PCZ-induced oxidative damage in the rat. Male Wistar rats (160–180 g) were randomized into five groups (n = 5/group): I (control), II PCZ-treated (2 mg/kg body weight (bw) for seven days); III pre-treated with QCT (20 mg/kg bw… Expand
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