Quenching of fluorescence by meclizine, a probe study for structural and conformational changes in human serum albumin

@article{Ariga2017QuenchingOF,
  title={Quenching of fluorescence by meclizine, a probe study for structural and conformational changes in human serum albumin},
  author={Girish G. Ariga and P. Naik and S. Nandibewoor and S. Chimatadar},
  journal={Journal of Biomolecular Structure and Dynamics},
  year={2017},
  volume={35},
  pages={3161 - 3175}
}
The goal of this study was to investigate the interactions between meclizine (MEC) and human serum albumin (HSA) under physiological conditions by different spectroscopies and molecular modeling technique. The drug, MEC quenched the intrinsic fluorescence of HSA and the analysis of the results revealed that static quenching mechanism. The binding of MEC quenches the HSA fluorescence; stoichiometry was 1:1 interaction. Thermodynamic quantities were calculated at different temperatures suggested… Expand
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