Quelling the storm: utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm.

@article{Walsh2011QuellingTS,
  title={Quelling the storm: utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm.},
  author={Kevin B. Walsh and John R. Teijaro and H. K. Rosen and Michael B A Oldstone},
  journal={Immunologic research},
  year={2011},
  volume={51 1},
  pages={15-25}
}
Initial and early tissue injury associated with severe influenza virus infection is the result of both virus-mediated lysis of infected pulmonary cells coupled with an exuberant immune response generated against the virus. The excessive host immune response associated with influenza virus infection has been termed "cytokine storm." Therapies that target virus replication are available; however, the selective pressure by such antiviral drugs on the virus often results in mutation and the escape… CONTINUE READING