Queer currents, steady rhythms, and drunken da neurons. Focus on "hyperpolarization-activated cation current (Ih) is an ethanol target in midbrain dopamine neurons of mice".

@article{Lupica2006QueerCS,
  title={Queer currents, steady rhythms, and drunken da neurons. Focus on "hyperpolarization-activated cation current (Ih) is an ethanol target in midbrain dopamine neurons of mice".},
  author={Carl R. Lupica and Mark S Brodie},
  journal={Journal of neurophysiology},
  year={2006},
  volume={95 2},
  pages={585-6}
}
Currents derived from hyperpolarization-activated cation channels (Ih channels) were once referred to as “queer currents (Iq)” because they were unusual in their large amplitudes, their activation by hyperpolarization, and their lack of inactivation during sustained hyperpolarization of the cellular membrane (Halliwell and Adams 1982). Today, we know that Ih channels are voltage-dependent ion channels that gate K and Na and are derived from at least four genes (hyperpolarization-activated… CONTINUE READING