Queenslandon, a new antifungal compound produced by Chrysosporium queenslandicum: production, isolation and structure elucidation.

  title={Queenslandon, a new antifungal compound produced by Chrysosporium queenslandicum: production, isolation and structure elucidation.},
  author={Yasutaka Hoshino and Veneta Bojanova Ivanova and Katsukiyo Yazawa and Akikazu Ando and Yuzuru Mikami and Sherif Mohamed Zaki and Al‐Zaharaa A. Karam and Youssef A. Youssef and Udo Gr{\"a}fe},
  journal={The Journal of antibiotics},
  volume={55 5},
Rare β-Resorcylic Acid Derivatives from a Halophyte-Associated Fungus Colletotrichum gloeosporioides JS0419 and Their Antifungal Activities
Six new β-resorcylic acid derivatives were isolated from a halophyte-associated fungus, Colletotrichum gloeosporioides JS0419, and monocillin I and radicicol showed potent antifungal activities against Cryptococcus neoformans, comparable to clinically available antIFungal agents and radICicol showed weak antIfungal activity against Candida albicans.
Beta resorcylic acid lactones (RALs) from fungi: chemistry, biology, and biosynthesis.
In this review, more than 100 RAL-type of compounds are structurally classified into three groups; 14-membered RALs with 17R configuration, 14- Membered RALS with 17S configuration, and benzopyranones/benzofuranones, and they are reviewed comprehensively in terms of chemistry, biological activities, and biosynthetic pathways.
Bioactive compounds from Chrysosporium multifidum, a fungus isolated from Hermetia illucens gut microbiota
The isolation and identification of the fungus Chrysosporium multifidum as a component of the microbiota from the larval gut of Hermetia illucens and extract from the broth culture showed moderate activity on a strain of methicillin-resistant Staphylococcus aureus.
Highly Diastereoselective Synthesis of Syn-1,3-Dihydroxyketone Motifs from Propargylic Alcohols via Unusual Spiroepoxide Intermediates.
The reaction sequence involves regioselective cyclisation of propargylic alcohols with incorporation of a triketone to give enol dioxolanes that are then diastereoselectively epoxidised to form unusual spiroepoxide intermediates and remarkably can be efficiently carried out as a one-pot process with no loss of overall yield or diasteretivity.
Identification and characterization of compounds from Chrysosporium multifidum, a fungus with moderate antimicrobial activity isolated from Hermetia illucens gut microbiota
The gut microbiota of insects is composed of a wide range of microorganisms which produce bioactive compounds that protect their host from pathogenic attack. In the present study, we isolate and
Resorcylic acid lactones (RALs) and their structural congeners: recent advances in their biosynthesis, chemical synthesis and biology
Resorcylic acid lactones (RALs) are naturally occurring 14-membered macrolactones that constitute a class of polyketides derived from fungal metabolites and that possess significant and promising
Chrysosporium queenslandicum: a potent keratinophilic fungus for keratinous waste degradation
PurposeKeratinous wastes are the solid environmental pollutant generated from poultry farms, slaughterhouses and barber’s shops. The aim of the present study is the degradation of keratinous wastes
Effect of Culture Media and Environmental Conditions on Mycelium Growth and Sporulation of Chrysosporium queenslandicum
The influence of various culture media and environmental factors play an imperative role in the growth of mycelia and sporulation of keratinophilic fungi. Fungi grow up best at optimal temperature,


Production of a family of kinase-inhibiting lactones from fungal fermentations.
During the course of our screening for natural products from fungi, extracts of several cultures were found to make a family of related resorcylic acid lactone compounds, which are potent inhibitors
Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEK.
A resorcylic acid lactone, L-783,277, isolated from a Phoma sp. (ATCC 74403) which came from the fruitbody of Helvella acetabulum, is a potent and specific inhibitor of MEK (Map kinase kinase).
Analysis of naturally occurring mycotoxins in feedstuffs and food.
Aflatoxins, zearalenone, deoxynivalenol, fumonisins, and their respective metabolites require specific procedures for their determination because of their diverse chemistry and occurrence in complex
Isolation and characterization of zearalenone sulfate produced by Fusarium spp
The structure of the novel metabolite was determined to be zearalenone-4-sulfate on the basis of fast-atom-bombardment mass spectrometry, proton nuclear magnetic resonance, UV spectroscopy, and by chemical and enzymatic reactions.
Rapid screening method for zearalenone in corn, wheat and sorghum
A rapid and sensitive screening method has been developed for zearalenone in corn, wheat and sorghum. The method is based on minicolumn chromatography, and an analysis can be completed in ca. 10 min
Metabolites of Dactylaria lutea. The structures of dactylariol and the antiprotozoal antibiotic dactylarin.
The structure and relative configuration of dactylariol are established from spectroscopic studies, and its absolute configuration is proposed as 1R, 2R, 3R by virtue of its co-occurrence with altersolanol B.