Quazepam kinetics in the elderly

@article{Hilbert1984QuazepamKI,
  title={Quazepam kinetics in the elderly},
  author={James M. Hilbert and Menger Chung and Elaine R. Radwanski and Richard Gural and Samson Symchowicz and Nicola Zampaglione},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1984},
  volume={36}
}
The kinetics of quazepam, a benzodiazepine hypnotic, was studied in 10 geriatric subjects. Each received one 15‐mg tablet of quazepam. Blood samples were collected before and at specified times (up to 672 hr) after dosing. Plasma concentrations of quazepam and its two major active plasma metabolites, 2‐oxoquazepam and N‐desalkyl‐2‐oxoquazepam (N‐desalkylflurazepam), were determined by specific GLC methods. Kinetics were best described by a two‐compartment open model with first‐order absorption… 
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The purpose of this review is to provide an update on distinguishing features of quazepam with regard to its pharmacology, pharmacokinetics, sleep efficacy and potential adverse effects compared to other agents used for insomnia.
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GLC determination of quaze - pam and two major metabolites in human plasma
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