Quazepam and temazepam: Effects of short‐ and intermediate‐term use and withdrawal

@article{Kales1986QuazepamAT,
  title={Quazepam and temazepam: Effects of short‐ and intermediate‐term use and withdrawal},
  author={A. Kales and E. Bixler and C. Soldatos and A. Vela‐Bueno and J. Jacoby and J. Kales},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1986},
  volume={39}
}
Two benzodiazepine hypnotics, one with an intermediate elimination t½ (temazepam, 15 mg) and the other with a long t½ (quazepam, 15 mg), were evaluated in 22‐ night sleep laboratory studies. The effectiveness and side effects of these benzodiazepines were assessed during short‐ and intermediate term use. Subjects were also assessed for the presence of rebound insomnia after abrupt withdrawal. Quazepam, 15 mg, was significantly effective in improving sleep both with short‐ and intermediate‐term… Expand
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References

SHOWING 1-10 OF 63 REFERENCES
Quazepam and flurazepam: Long‐term use and extended withdrawal
TLDR
The data suggest that the optimal dose of quazepam is 15 mg, and some loss of effectiveness was noted during long‐term use of both doses of quzepam and, to a lesser extent, of flurazepams. Expand
Effectiveness of Temazepam with Short‐, Intermediate‐, and Long‐Term Use: Sleep Laboratory Evaluation
TLDR
Effectiveness of 30 mg temazepam for inducing and maintaining sleep was evaluated in the sleep laboratory in six insomniac subjects under conditions of short-, intermediate-, and long-term drug administration, and effectiveness was not demonstrated for sleep maintenance. Expand
Dose‐response studies of quazepam
TLDR
The efficacy and comparatively less severe side effects of the 7.5‐and 15‐mg doses of quazepam suggest that these doses may be optimal when the drug is considered for the adjunctive treatment of insomnia. Expand
Effectiveness of hypnotic drugs with prolonged use: Flurazepam and pentobarbital
TLDR
Pentobarbital was found to be effective in inducing and maintaining sleep only with short‐term drug administration, which strongly suggests that it is of limited value for insomniac patients who require nightly medication beyond short-term use. Expand
Dose—Response Studies of Lormetazepam: Efficacy, Side Effects, and Rebound Insomnia
TLDR
There was less efficacy on the later drug nights, indicating a potential for the development of tolerance over a relatively short period of time, and following drug withdrawal, there was a dose‐related worsening of sleep above baseline levels (rebound insomnia). Expand
Hypnotic efficacy of temazepam: a long-term sleep laboratory evaluation.
TLDR
Temazepam seemed to be both safe and effective at doses of 15 and 30 mg with up to 5 weeks of ingestion, and no evidence was found for development of tolerance or rebound effects. Expand
Evaluation of Temazepam as a Hypnotic
TLDR
Studies on tolerance, metabolism and carry‐over effects have shown that temazepam has no long‐acting metabolites and does not affect waking function following use at bedtime, and in patients for whom hypnotic medication is appropriate, it should be an effective drug for reducing most symptoms of insomnia. Expand
Lorazepam—Efficacy, side effects, and rebound phenomena
TLDR
The results suggest that while 4 mg lorazepam may be effective in inducing and maintaining sleep, this dose induces clinically significant side effects that are followed by consistent rebound phenomena after withdrawal. Expand
Quazepam, A New Benzodiazepine Hypnotic: Intermediate‐Term Sleep Laboratory Evaluation
TLDR
Data regarding long-term safety or tolerance of the drug suggest that quazepam is well tolerated and that its pharmacological effects are similar to those of other benzodiazepines. Expand
Hypnotic Efficacy of Triazolam: Sleep Laboratory Evaluation of Intermediate‐Term Effectiveness
TLDR
The data indicate that triazolam is effective for short-term use, loses most of its effectiveness with intermediate- term use, and its withdrawal is followed by a significant sorsening of sleep. Expand
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