Quazepam and temazepam: Effects of short‐ and intermediate‐term use and withdrawal

@article{Kales1986QuazepamAT,
  title={Quazepam and temazepam: Effects of short‐ and intermediate‐term use and withdrawal},
  author={Anthony Kales and Edward O. Bixler and Constantin R. Soldatos and Antonio Vela‐bueno and Judith A. Jacoby and Joyce D. Kales},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1986},
  volume={39}
}
Two benzodiazepine hypnotics, one with an intermediate elimination t½ (temazepam, 15 mg) and the other with a long t½ (quazepam, 15 mg), were evaluated in 22‐ night sleep laboratory studies. The effectiveness and side effects of these benzodiazepines were assessed during short‐ and intermediate term use. Subjects were also assessed for the presence of rebound insomnia after abrupt withdrawal. Quazepam, 15 mg, was significantly effective in improving sleep both with short‐ and intermediate‐term… 
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Comparison of short and long half‐life benzodiazepine hypnotics: Triazolam and quazepam
TLDR
The 0.25 mg dose of triazolam, which is being prescribed increasingly, has a profile of side effects that is similar to that of the 0.5 mg dose, and is associated with sleep and mood disturbances whereas quazepam exerted carryover effectiveness.
Quazepam: Hypnotic Efficacy and Side Effects
  • A. Kales
  • Medicine, Psychology
    Pharmacotherapy
  • 1990
TLDR
Quazepam is a benzodiazepine hypnotic that can be useful in the adjunctive pharmacologic treatment of insomnia and is more effective with short‐term use, and with continued use it maintains its efficacy in contrast to both of these drugs which show rapid development of tolerance.
Rebound insomnia after only brief and intermittent use of rapidly eliminated benzodiazepines
TLDR
It is indicated that even under conditions of brief, intermittent use and withdrawal, triazolam and, to a lesser degree, temazepam produce rebound insomnia after abrupt withdrawal, thereby predisposing to drug‐taking behavior and increasing the potential for drug dependence.
Temazepam 7.5 mg: effects on sleep in elderly insomniacs
TLDR
Temazepam, 7.5 mg is effective in elderly subjects with short-term use and has a minimum of adverse effects and its low propensity for producing rebound insomnia, can be effectively used in this manner.
Reintroduction of quazepam: an update on comparative hypnotic and adverse effects.
  • N. Moniri
  • Psychology, Biology
    International clinical psychopharmacology
  • 2019
TLDR
The purpose of this review is to provide an update on distinguishing features of quazepam with regard to its pharmacology, pharmacokinetics, sleep efficacy and potential adverse effects compared to other agents used for insomnia.
Rebound insomnia and newer hypnotics
  • M. Lader
  • Psychology, Medicine
    Psychopharmacology
  • 2005
TLDR
Present evidence, while limited, is consistent with claims of less rebound potential than older benzodiazepine hypnotics of equivalent duration of action, but further rigorous studies are essential before these claims can be totally accepted.
Rebound Insomnia: A Critical Review
TLDR
The results indicate that rebound insomnia is a distinct possibility after discontinuation of triazolam in both insomniacs and normal controls and is greater with the short half-life as compared with the long half- life benzodiazepines.
Benzodiazepine hypnotics and insomnia.
In summary, it is proposed that the more frequent or severe side effects associated with the newer triazolo-benzodiazepines are related to an interaction of several factors, including rapid…
The benzodiazepine withdrawal syndrome.
Physiological dependence on benzodiazepines is accompanied by a withdrawal syndrome which is typically characterized by sleep disturbance, irritability, increased tension and anxiety, panic attacks,…
The dependence potential of short half-life benzodiazepines: a meta-analysis.
TLDR
The present meta-analysis confirms clinical impressions of the greater dependence potential of short vs long half-life benzodiazepines and advises doctors, patients, and policymakers to be informed so as to avoid harm to the public health through unintended drug dependence.
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TLDR
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