Quazepam and temazepam: Effects of short‐ and intermediate‐term use and withdrawal

@article{Kales1986QuazepamAT,
  title={Quazepam and temazepam: Effects of short‐ and intermediate‐term use and withdrawal},
  author={A. Kales and E. Bixler and C. Soldatos and A. Vela‐Bueno and J. Jacoby and J. Kales},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1986},
  volume={39}
}
Two benzodiazepine hypnotics, one with an intermediate elimination t½ (temazepam, 15 mg) and the other with a long t½ (quazepam, 15 mg), were evaluated in 22‐ night sleep laboratory studies. The effectiveness and side effects of these benzodiazepines were assessed during short‐ and intermediate term use. Subjects were also assessed for the presence of rebound insomnia after abrupt withdrawal. Quazepam, 15 mg, was significantly effective in improving sleep both with short‐ and intermediate‐term… Expand
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Quazepam is a benzodiazepine hypnotic that can be useful in the adjunctive pharmacologic treatment of insomnia and is more effective with short‐term use, and with continued use it maintains its efficacy in contrast to both of these drugs which show rapid development of tolerance. Expand
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It is indicated that even under conditions of brief, intermittent use and withdrawal, triazolam and, to a lesser degree, temazepam produce rebound insomnia after abrupt withdrawal, thereby predisposing to drug‐taking behavior and increasing the potential for drug dependence. Expand
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Temazepam, 7.5 mg is effective in elderly subjects with short-term use and has a minimum of adverse effects and its low propensity for producing rebound insomnia, can be effectively used in this manner. Expand
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  • Medicine
  • International clinical psychopharmacology
  • 2019
TLDR
The purpose of this review is to provide an update on distinguishing features of quazepam with regard to its pharmacology, pharmacokinetics, sleep efficacy and potential adverse effects compared to other agents used for insomnia. Expand
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  • Psychology, Medicine
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Present evidence, while limited, is consistent with claims of less rebound potential than older benzodiazepine hypnotics of equivalent duration of action, but further rigorous studies are essential before these claims can be totally accepted. Expand
Rebound Insomnia: A Critical Review
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The results indicate that rebound insomnia is a distinct possibility after discontinuation of triazolam in both insomniacs and normal controls and is greater with the short half-life as compared with the long half- life benzodiazepines. Expand
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