Quazepam: Hypnotic Efficacy and Side Effects
@article{Kales1990QuazepamHE, title={Quazepam: Hypnotic Efficacy and Side Effects}, author={Anthony Kales}, journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy}, year={1990}, volume={10} }
Quazepam is a benzodiazepine hypnotic that can be useful in the adjunctive pharmacologic treatment of insomnia. It is slowly eliminated due to the long elimination half‐lives of the parent compound and its two active metabolites, 2‐oxoqua‐zepam and N‐desalkyl‐2‐oxoquazepam. This drug is recommended in doses of 15 mg for adults and 7.5 mg for geriatric patients. Sleep laboratory studies and clinical trials have shown that the 15 mg dose is quite efficacious for inducing and maintaining sleep not…
23 Citations
Hypnotic effects of low doses of quazepam in older insomniacs.
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Time effects of food intake on the pharmacokinetics and pharmacodynamics of quazepam.
- Medicine, BiologyBritish journal of clinical pharmacology
- 2003
The dosing of quazepam after a long period of ordinary fasting might reduce its efficacy because a 3 h interval between the timing of the evening meal and bedtime administration of hypnotics is regarded as normal in daily life.
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- Psychology, MedicinePsychiatry and clinical neurosciences
- 2003
Subjective hangover effects assessed by SSS and SEQ in the morning were prominent for flunitrazepam and quazepam relative to triazolam, whereas objective indices such as MSLT or activity counts obtained in actigraphy indicated a marked hangover effect of quazEPam compared with the other two compounds restrictively in the afternoon, which were nearly in accordance with their pharmacokinetic profiles.
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