Quazepam: Hypnotic Efficacy and Side Effects

@article{Kales1990QuazepamHE,
  title={Quazepam: Hypnotic Efficacy and Side Effects},
  author={Anthony Kales},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={1990},
  volume={10}
}
  • A. Kales
  • Published 2 January 1990
  • Medicine, Psychology
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Quazepam is a benzodiazepine hypnotic that can be useful in the adjunctive pharmacologic treatment of insomnia. It is slowly eliminated due to the long elimination half‐lives of the parent compound and its two active metabolites, 2‐oxoqua‐zepam and N‐desalkyl‐2‐oxoquazepam. This drug is recommended in doses of 15 mg for adults and 7.5 mg for geriatric patients. Sleep laboratory studies and clinical trials have shown that the 15 mg dose is quite efficacious for inducing and maintaining sleep not… 
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Analyses of plasma concentrations of quzepam and its metabolites suggested the continued drug effects on sleep during recovery are due to the metabolite desalkylflurazepam, and the safety evaluation done by means of adverse drug event assessments and postsleep questionnaires was minimal.
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O Ongoing pharmaceutical research has the objective of developing drug delivery innovations that can optimize hypnotic drug action by regulation of release and systemic exposure to short half-life BZ agonists.
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  • M. Lader
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Present evidence, while limited, is consistent with claims of less rebound potential than older benzodiazepine hypnotics of equivalent duration of action, but further rigorous studies are essential before these claims can be totally accepted.
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This chapter will discuss the uses of hypnotics and sedatives for the treatment of insomnia and outline appropriate management strategies for effective treatment outcomes.
Drug interaction between St John's Wort and quazepam.
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It is suggested that SJW decreases plasma quazepam concentrations, probably by enhancing CYP3A4 activity, but does not influence the pharmacodynamic effects of the drug.
Insomnia Management and Hypnotic Benzodiazepine Therapeutics
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How common insomnia is and how important it is for health professionals to understand hypnotic drug use are indicated are indicated.
Time effects of food intake on the pharmacokinetics and pharmacodynamics of quazepam.
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The dosing of quazepam after a long period of ordinary fasting might reduce its efficacy because a 3 h interval between the timing of the evening meal and bedtime administration of hypnotics is regarded as normal in daily life.
Comparison of hangover effects among triazolam, flunitrazepam and quazepam in healthy subjects: A preliminary report
TLDR
Subjective hangover effects assessed by SSS and SEQ in the morning were prominent for flunitrazepam and quazepam relative to triazolam, whereas objective indices such as MSLT or activity counts obtained in actigraphy indicated a marked hangover effect of quazEPam compared with the other two compounds restrictively in the afternoon, which were nearly in accordance with their pharmacokinetic profiles.
Beyond Benzodiazepines: Alternative Pharmacologic Agents for the Treatment of Insomnia
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Novel nonbenzodiazepine hypnotics including zolpidem, zopiclone, and zaleplon, as well as nonprescription products such as valerian and melatonin, are reviewed in detail to provide an overview of the pharmacologic therapy of insomnia.
The Black Book of Psychotropic Dosing and Monitoring.
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Since the last update of The Black Book in 2007, new psychotropics have expanded existing classes of drugs, while others have challenged the well-worn nomenclature of psychiatric agents.
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