Quazepam, A New Benzodiazepine Hypnotic: Intermediate‐Term Sleep Laboratory Evaluation

@article{Kales1980QuazepamAN,
  title={Quazepam, A New Benzodiazepine Hypnotic: Intermediate‐Term Sleep Laboratory Evaluation},
  author={Anthony Kales and Martin B. Scharf and Constantin R. Soldatos and Edward O. Bixler and Susan B Bianchi and Paula K. Schweitzer},
  journal={The Journal of Clinical Pharmacology},
  year={1980},
  volume={20}
}
When quazepam was compared with fiurazepam in animal studies assessing sedation and ataxia, quazepam appeared to be somewhat more potent than fiurazepam, but caused less ataxia.1 Data regarding long-term safety or tolerance of the drug are not yet available, but rising single-dose tolerance studies suggest that quazepam is well tolerated and that its pharmacological effects are similar to those of other benzodiazepines.’ The primary objective of the current study was to evaluate, in the sleep… 
Quazepam: Hypnotic Efficacy and Side Effects
  • A. Kales
  • Medicine, Psychology
    Pharmacotherapy
  • 1990
TLDR
Quazepam is a benzodiazepine hypnotic that can be useful in the adjunctive pharmacologic treatment of insomnia and is more effective with short‐term use, and with continued use it maintains its efficacy in contrast to both of these drugs which show rapid development of tolerance.
Comparison of short and long half‐life benzodiazepine hypnotics: Triazolam and quazepam
TLDR
The 0.25 mg dose of triazolam, which is being prescribed increasingly, has a profile of side effects that is similar to that of the 0.5 mg dose, and is associated with sleep and mood disturbances whereas quazepam exerted carryover effectiveness.
Quazepam and temazepam: Effects of short‐ and intermediate‐term use and withdrawal
TLDR
Although temazepam was effective for maintaining sleep with short‐term use, there was rapid development of tolerance for this effect with intermediate‐ term use, and quazEPam had carryover effectiveness.
Quazepam and flurazepam: Long‐term use and extended withdrawal
TLDR
The data suggest that the optimal dose of quazepam is 15 mg, and some loss of effectiveness was noted during long‐term use of both doses of quzepam and, to a lesser extent, of flurazepams.
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TLDR
The efficacy and comparatively less severe side effects of the 7.5‐and 15‐mg doses of quazepam suggest that these doses may be optimal when the drug is considered for the adjunctive treatment of insomnia.
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  • Psychology, Biology
    International clinical psychopharmacology
  • 2019
TLDR
The purpose of this review is to provide an update on distinguishing features of quazepam with regard to its pharmacology, pharmacokinetics, sleep efficacy and potential adverse effects compared to other agents used for insomnia.
Comparison of the effects of quazepam and triazolam on cognitive-neuromotor performance
TLDR
Performance scores were already showing recovery from peak impairment 2 h post-drug ingestion, although quazepam's potent N-desalkylflurazepAM metabolite has been found to maintain a maximum plateau level from 2 to 24 h.
Effects of quazepam as a preoperative night hypnotic: comparison with brotizolam
TLDR
The preoperative night hypnotics, quazepam and brotizolam improved sleep before surgery; the frequency of nocturnal awakening and dreaming decreased, and the total duration of sleep the night before surgery increased.
A Comparative 25‐Night Sleep Laboratory Study on the Effects of Quazepam and Triazolam on Chronic Insomniacs
TLDR
With quazepam, rebound insomnia was not observed at any time during the seven‐day withdrawal period, and both drugs increased the total sleep time during their administration and improved the subjective quality of sleep.
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