Quaternary structure of nucleoside diphosphate kinases.

  title={Quaternary structure of nucleoside diphosphate kinases.},
  author={L Lascu and Anna Giartosio and St{\'e}phane Ransac and Muriel Erent},
  journal={Journal of bioenergetics and biomembranes},
  volume={32 3},
Nucleoside (NDP) diphosphate kinases are oligomeric enzymes. Most are hexameric, but some bacterial enzymes are tetrameric. Hexamers and tetramers are constructed by assembling identical dimers. The hexameric structure is important for protein stability, as demonstrated by studies with natural mutants (the Killer-of-prune mutant of Drosophila NDP kinase and the S120G mutant of the human NDP kinase A in neuroblastomas) and with mutants obtained by site-directed mutagenesis. It is also essential… CONTINUE READING

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