Quaternary structure of coronavirus spikes in complex with carcinoembryonic antigen-related cell adhesion molecule cellular receptors.

Abstract

Oligomeric spike (S) glycoproteins extend from coronavirus membranes. These integral membrane proteins assemble within the endoplasmic reticulum of infected cells and are subsequently endoproteolyzed in the Golgi, generating noncovalently associated S1 and S2 fragments. Once on the surface of infected cells and virions, peripheral S1 fragments bind… (More)

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@article{Lewicki2002QuaternarySO, title={Quaternary structure of coronavirus spikes in complex with carcinoembryonic antigen-related cell adhesion molecule cellular receptors.}, author={Daniel N. Lewicki and Thomas M. Gallagher}, journal={The Journal of biological chemistry}, year={2002}, volume={277 22}, pages={19727-34} }