Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands

@article{Fass1999QuaternaryCI,
  title={Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands},
  author={D. Fass and C. Bogden and J. Berger},
  journal={Nature Structural Biology},
  year={1999},
  volume={6},
  pages={322-326}
}
Type II DNA topoisomerases mediate the passage of one DNA duplex through a transient break in another, an event essential for chromosome segregation and cell viability. The active sites of the type II topoisomerase dimer associate covalently with the DNA break-points and must separate by at least the width of the second DNA duplex to accommodate transport. A new structure of the Saccharomyces cerevisiae topoisomerase II DNA-binding and cleavage core suggests that in addition to conformational… Expand

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