Quaternary ammonium glucuronide of croconazole in rabbits.

@article{Takeuchi1989QuaternaryAG,
  title={Quaternary ammonium glucuronide of croconazole in rabbits.},
  author={Masakazu Takeuchi and Masayuki Yoko Nakano and Kenji Mizojiri and Koji Iwatani and Yoshio Nakagawa and Junko Kikuchi and Yoshihiro Terui},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1989},
  volume={19 11},
  pages={1327-36}
}
1. A water-soluble croconazole glucuronide was isolated from the urine of rabbits dosed intravenously with croconazole, using XAD-2 column chromatography, reversed-phase RP-8 column chromatography and h.p.l.c. 2. beta-Glucuronidase hydrolysis liberated unchanged croconazole from the glucuronide. 3. Secondary ion mass spectra, i.r. and n.m.r. spectroscopic studies, including two-dimensional n.m.r. techniques (ROESY and HETCOR), showed the metabolite to be a quaternary ammonium glucuronide of… CONTINUE READING

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spectroscopic studies , including two - dimensional n.m.r . techniques ( ROESY and HETCOR ) , showed the metabolite to be a quaternary ammonium glucuronide of croconazole : i.e. a chemical bond exists between a nitrogen , having sp2 type orbital , in the imidazole ring of croconazole and the anomeric carbon of glucuronic acid .
spectroscopic studies , including two - dimensional n.m.r . techniques ( ROESY and HETCOR ) , showed the metabolite to be a quaternary ammonium glucuronide of croconazole : i.e. a chemical bond exists between a nitrogen , having sp2 type orbital , in the imidazole ring of croconazole and the anomeric carbon of glucuronic acid .
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