Quasispecies dynamics on a network of interacting genotypes and idiotypes: Applications to autoimmunity and immunodeficiency

  title={Quasispecies dynamics on a network of interacting genotypes and idiotypes: Applications to autoimmunity and immunodeficiency},
  author={Valmir Carneiro Barbosa and Raul Donangelo and S. R. Souza},
  journal={arXiv: Populations and Evolution},
In spite of their many facets, the phenomena of autoimmunity and immunodeficiency seem to be related to each other through the subtle links connecting retroviral mutation and action to immune response and adaptation. In a previous work, we introduced a network model of how a set of interrelated genotypes (called a quasispecies, in the stationary state) and a set of interrelated idiotypes (an idiotypic network) interact. That model, which does not cover the case of a retroviral quasispecies, was… Expand
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