Quasispecies and virus

@article{Domingo2018QuasispeciesAV,
  title={Quasispecies and virus},
  author={E. Domingo and C. Perales},
  journal={European Biophysics Journal},
  year={2018},
  volume={47},
  pages={443-457}
}
Quasispecies theory has been instrumental in the understanding of RNA virus population dynamics because it considered for the first time mutation as an integral part of the replication process. The key influences of quasispecies theory on experimental virology have been: (1) to disclose the mutant spectrum nature of viral populations and to evaluate its consequences; (2) to unveil collective properties of genome ensembles that can render a mutant spectrum a unit of selection; and (3) to… Expand
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