Quasi-hexagonal molecular packing in collagen fibrils
@article{Hulmes1979QuasihexagonalMP, title={Quasi-hexagonal molecular packing in collagen fibrils}, author={David J S Hulmes and Andrew D. Miller}, journal={Nature}, year={1979}, volume={282}, pages={878-880} }
Collagen molecules in native 66.8 nm (D) periodic fibrils are widely believed to be assembled into discrete, rope-like sub-structures, or microfibrils1–17. Several types of microfibril have been proposed (2,4,5,7- and 8-stranded), mainly on the basis of information contained in the medium angle X-ray diffraction patterns of native tendon fibres1,5–7. These patterns show a series of equatorial and near-equatorial Bragg reflections which indicate that the collagen molecules are arranged on a…
259 Citations
A new model for packing of type-I collagen molecules in the native fibril
- PhysicsBioscience reports
- 1981
A specific fibril model is presented consisting of bundles of five-stranded microfibrils, which are usually disordered but under lateral compression become ordered, and calculated intensities in the equatorial region of the x-ray diffraction pattern agree with observed values.
Molecular packing of type I collagen in tendon.
- PhysicsJournal of molecular biology
- 1998
A global search through combinations of molecular packing and molecular translation revealed that the sheet-type conformations cannot account for the observed low-angle off-meridional Bragg peak intensity distribution.
Compressed microfibril models of the native collagen fibril
- ChemistryNature
- 1980
Two models which contain five-stranded microfibrils compressed to place molecules (in cross-section) on a pseudo-hexagonal lattice are proposed, which are equivalent or related to the cell proposed by Hulmes and Miller1.
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- ChemistryNature
- 1980
It is argued here that until other characteristic parameters are taken into account, in particular the chemical cross-linking evidence, the packing problem is still unresolved.
Structure of Collagen Fibrils
- Biology
- 1985
Three clear features of the structure of collagen fibrils are recognised and probably not seriously disputed: axially, molecules are related by staggers of integral multiples of approximately 67nm, the near-equatorial X-ray diffraction pattern suggests a structure in an equatorial projection reminiscent of a two dimensional simple liquid, and some parts of the fibril that is crystalline or nearly so are suggested.
The molecular and fibrillar structure of collagen and its relationship to the mechanical properties of connective tissue.
- Chemistry, BiologyBiophysical chemistry
- 1988
Crystalline three‐dimensional packing is a general characteristic of type I collagen fibrils
- BiologyFEBS letters
- 1980
Computational study of packing a collagen‐like molecule: Quasi‐hexagonal vs “Smith” collagen microfibril model
- ChemistryBiopolymers
- 1996
The lateral packing of a collagen‐like molecule, CH3CO‐(Gly‐L‐Pro‐ L‐Pro)4‐NHCH3, has been examined by energy minimization with the ECEPP/3 force field and is found to be energetically more favorable than the Smith microfibril model.
References
SHOWING 1-10 OF 37 REFERENCES
Microfibrillar structure and packing of collagen: hydrophobic interactions.
- ChemistryJournal of molecular biology
- 1977
The intermolecular space of reconstituted collagen fibrils.
- ChemistryJournal of molecular biology
- 1973
EQUATORIAL X-RAY DIFFRACTION BY FIBROUS PROTEINS: SHORT-RANGE ORDER IN COLLAGEN, FEATHER KERATIN AND F-ACTIN.
- PhysicsJournal of molecular biology
- 1963
Structural Units in Collagen Fibrils
- BiologyNature
- 1954
It is of interest to note that evidence for structure of size approximately 200 A. is found in α-keratin5 and 230 A. in fibrin6, although the recurrence of this figure may be no more than coincidental.
The limiting collagen microfibril. The minimum structure demonstrating native axial periodicity.
- BiologyBiochimica et biophysica acta
- 1979
Modern theories of liquids and the diffuse equatorial X‐ray scattering from collagen
- Physics
- 1976
The idea that the lateral arrangement of a proportion of molecules in the collagen fibril displays a short-range two-dimensional liquid-like order is investigated and shown to be true. Theoretical…
Closest packing of two-stranded coiled-coils as a model for the collagen fibril.
- PhysicsBiochemical and biophysical research communications
- 1975