Quasi-consensus-based comparison of profile hidden Markov models for protein sequences

Abstract

A simple approach for the sensitive detection of distant relationships among protein families and for sequence-structure alignment via comparison of hidden Markov models based on their quasi-consensus sequences is presented. Using a previously published benchmark dataset, the approach is demonstrated to give better homology detection and yield alignments… (More)
DOI: 10.1093/bioinformatics/bti374

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