Quantum mechanical calculations useful for determining the mechanism of action of fosfomycin.

Abstract

CNDO/2 calculations were performed to determine at the molecular level the mechanism of action of the antibiotic fosfomycin, (--)-(1R,2S)-(1,2-epoxypropyl)phosphonic acid. Fosfomycin, a bacterial cell wall inhibitor, is known to act as a competitive inhibitor of N-acetylglucosamine-3-O-enolpyruvyl transferase, the normal substrate of which is… (More)

Topics

Cite this paper

@article{Smeyers1983QuantumMC, title={Quantum mechanical calculations useful for determining the mechanism of action of fosfomycin.}, author={Yves G. Smeyers and Alfonso Hern{\'a}ndez-Laguna and C Von Carstenn-Lichterfelde}, journal={Journal of pharmaceutical sciences}, year={1983}, volume={72 9}, pages={1011-4} }