Quantum interactive dualism: From Beck and Eccles tunneling model of exocytosis to molecular biology of SNARE zipping

  title={Quantum interactive dualism: From Beck and Eccles tunneling model of exocytosis to molecular biology of SNARE zipping},
  author={Danko D. Georgiev and J. Glazebrook},
  journal={Biomedical Reviews},
We commence this review by outlining the challenges faced by physical theories of consciousness and briefly describe the two main approaches based on classical or quantum mechanics. Next, we provide a detailed exposition of the motivation, the theoretical construction and experimental falsification of the celebrated model due to Beck and Eccles concerning mind-brain interaction purported to operate at the sites of neurotransmitter release in the brain. Finally, we propose our own model of a… Expand

Figures from this paper

The quantum physics of synaptic communication via the SNARE protein complex.
A molecular upgrade of the Beck and Eccles model of neurotransmitter release at synapses in the human cerebral cortex is provided by identifying the quantum quasiparticles as Davydov solitons that twist the protein α-helices and trigger exocytosis of synaptic vesicles through helical zipping of the SNARE protein complex. Expand
Quantum information theoretic approach to the mind-brain problem.
  • Danko D. Georgiev
  • Medicine, Computer Science
  • Progress in biophysics and molecular biology
  • 2020
Comprising consciousness of unobservable quantum information integrated in quantum brain states explains the origin of the inner privacy of conscious experiences and revisits the dynamic timescale of conscious processes to picosecond conformational transitions of neural biomolecules. Expand
Towards a Coherent Application of the Beck-Eccles Quantum Trigger
Experimental results from several recent studies of the effects of mindfulness meditation on attentional skills suggest that volition can be used to induce significant changes in the brain’s ability to maintain focus on a single stimulus. Expand
Does Consciousness-Collapse Quantum Mechanics Facilitate Dualistic Mental Causation?
One of the most serious challenges (if not the most serious challenge) for interactive psycho-physical dualism (henceforth interactive dualism or ID) is the so-called ‘interaction problem’. It hasExpand
No-go Theorem for Stapp’s Quantum Zeno Model of Mind-Brain Interaction
I commence this work with a comprehensive outline of a recent no-go quantum informational theorem and discuss its implications for Stapp’s quantum mind model. Then I provide results from Monte CarloExpand
Inner privacy of conscious experiences and quantum information
Identifying consciousness with the unobservable quantum information contained by quantum physical brain states allows for application of quantum information theorems to resolve possible paradoxes created by the inner privacy of conscious experiences, and explains how the observable brain is constructed by accessible bits of classical information that are bound by Holevo's theorem. Expand
Chalmers’ Principle of Organizational Invariance Makes Consciousness Fundamental but Meaningless Spectator of Its Own Drama
It is argued that if consciousness is a fundamental ingredient of reality then no any psychophysical law such as Chalmers' principle of organizational invariance is needed to keep coherence betweenExpand


The causal consciousness: beta-neurexin promotes neuromediator release via vibrational multidimensional tunneling
Epiphenomenalism is shown to be absurd because the development of consciousness must be explainable through natural selection. A detailed neuromolecular basis of the neuromediator release is givenExpand
Synaptic Quantum Tunnelling in Brain Activity
In the struggle about the role of monism and dualism as basic concepts of the mind-brain relation the indeterminacy of quantum events has led an increasing number of authors to postulate quantumExpand
SNARE proteins as molecular masters of interneuronal communication
The high quality of both the visualization of individual nerve cells and the work performed on studying the anatomy of the central nervous system lead Ramon y Cajal to the conclusion that axons output the nervous impulses to the dendrites or the soma of other target neurons. Expand
Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+
It is shown that, before the Ca2+ trigger, synaptotagmin interacts with SNARE proteins in the target membrane to halt SNARE complex assembly at a step after donor vesicles attach, or dock, to target membranes, which results in fusion complexes that drive rapid, highly efficient lipid mixing. Expand
How SNARE molecules mediate membrane fusion: recent insights from molecular simulations.
Recent advances in the understanding of SNARE-mediated membrane fusion by molecular simulations are reviewed, showing SNARE complexes to also overcome subsequent fusion barriers and to actively guide the fusion reaction up to the expansion of the fusion pore. Expand
Volatile Anesthetics Bind Rat Synaptic Snare Proteins
SNARE proteins are potential synaptic targets of volatile anesthetics because of their ability to bind to halothane and isoflurane and the fact that they form the ternary SNARE complex. Expand
New insights into enzyme catalysis. Ground state tunnelling driven by protein dynamics.
The theoretical development, and verification by experiment, of a role for protein dynamics in driving enzymatic H-tunnelling is presented and it is suggested that the kinetic isotope effect, during rupture of a C-H/C-D bond, can assume values interpreted previously as indicating classical transfer. Expand
SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils.
It is concluded that SNAP-25 can interact with both syntaxin and synaptobrevin and that binding may be mediated by alpha-helical domains that form intermolecular coiled-coil structures. Expand
Can Quantum Processes Control Synaptic Emission?
  • F. Beck
  • Physics, Computer Science
  • Int. J. Neural Syst.
  • 1996
A model for the quantal emission process at the synaptic cleft is presented and related to the mechanism of electron transfer between different molecular states, as described by Marcus theory. Expand
Calcium‐Dependent Dissociation of Synaptotagmin from Synaptic SNARE Complexes
These findings are consistent with models in which the Ca2+‐triggered release of synaptotagmin precedes vesicle fusion, and suggest that constitutive SNARE complex disassembly occurs in undocked synaptic vesicles. Expand