Quantum dots-based in situ molecular imaging of dynamic changes of collagen IV during cancer invasion.

Abstract

Cancer invasion and metastasis remains the root cause of mortality. This process involves alterations of tumor microenvironment, particularly the remodeling of extracellular matrix, characterized by collagen IV uncoiling, degradation, fragments deposition and cross-linking. Quantum dots-labeled molecular probes are promising platforms to simultaneously… (More)
DOI: 10.1016/j.biomaterials.2013.07.069

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