Quantum dot ligands provide new insights into erbB/HER receptor–mediated signal transduction

@article{Lidke2004QuantumDL,
  title={Quantum dot ligands provide new insights into erbB/HER receptor–mediated signal transduction},
  author={Diane S. Lidke and Peter A. J. Nagy and R. Heintzmann and Donna J. Arndt-Jovin and Janine N. Post and Hern{\'a}n E. Grecco and Elizabeth Andrea Jares-Erijman and Thomas M. Jovin},
  journal={Nature Biotechnology},
  year={2004},
  volume={22},
  pages={198-203}
}
The erbB/HER family of transmembrane receptor tyrosine kinases (RTKs) mediate cellular responses to epidermal growth factor (EGF) and related ligands. We have imaged the early stages of RTK-dependent signaling in living cells using: (i) stable expression of erbB1/2/3 fused with visible fluorescent proteins (VFPs), (ii) fluorescent quantum dots (QDs) bearing epidermal growth factor (EGF-QD) and (iii) continuous confocal laser scanning microscopy and flow cytometry. Here we demonstrate that EGF… CONTINUE READING

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