Quantum dot-insect neuropeptide conjugates for fluorescence imaging, transfection, and nucleus targeting of living cells.

@article{Biju2007QuantumDN,
  title={Quantum dot-insect neuropeptide conjugates for fluorescence imaging, transfection, and nucleus targeting of living cells.},
  author={Vasudevanpillai Biju and Damodaran Muraleedharan and Ken-ichi Nakayama and Yasuo Shinohara and Tamitake Itoh and Yoshinobu Baba and Mitsuru Ishikawa},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2007},
  volume={23 20},
  pages={
          10254-61
        }
}
We identified an insect neuropeptide, namely, allatostatin 1 from Drosophila melanogaster, that transfects living NIH 3T3 and A431 human epidermoid carcinoma cells and transports quantum dots (QDs) inside the cytoplasm and even the nucleus of the cells. QD-conjugated biomolecules are valuable resources for visualizing the structures and functions of biological systems both in vivo and in vitro. Here, we selected allatostatin 1, Ala-Pro-Ser-Gly-Ala-Gln-Arg-Leu-Tyr-Gly-Phe-Gly-Leu-NH2, conjugated… CONTINUE READING
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