Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response.

@article{Anikeeva2006QuantumDB,
  title={Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response.},
  author={Nadia Anikeeva and Tatiana Lebedeva and Aaron R. Clapp and E. R. Goldman and Michael L. Dustin and Hedi Mattoussi and Yuri Sykulev},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 45},
  pages={16846-51}
}
Cytotoxic T lymphocytes (CTL) can respond to a few viral peptide-MHC-I (pMHC-I) complexes among a myriad of virus-unrelated endogenous self pMHC-I complexes displayed on virus-infected cells. To elucidate the molecular recognition events on live CTL, we have utilized a self-assembled biosensor composed of semiconductor nanocrystals, quantum dots, carrying a controlled number of virus-derived (cognate) and other (noncognate) pMHC-I complexes and examined their recognition by antigen-specific T… CONTINUE READING

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