Quantity of phenibut in dietary supplements before and after FDA warnings

@article{Cohen2021QuantityOP,
  title={Quantity of phenibut in dietary supplements before and after FDA warnings},
  author={Pieter A. Cohen and Ross Ellison and John C Travis and Slava V Gaufberg and Roy R. Gerona},
  journal={Clinical Toxicology},
  year={2021},
  volume={60},
  pages={486 - 488}
}
Abstract Introduction Phenibut is used to treat anxiety, insomnia, alcohol withdrawal and other conditions in Russia. The drug, however, has abuse potential and may cause lethargy, delirium, psychosis and coma. In the United States (US), the US Food and Drug Administration (FDA) has never approved the use of phenibut as a prescription medication, but the drug is available over-the-counter in dietary supplements. More than 80 cases of coma and death have been associated with phenibut consumption… 

References

SHOWING 1-10 OF 11 REFERENCES
Phenibut (β-Phenyl-γ-Aminobutyric Acid): an Easily Obtainable “Dietary Supplement” With Propensities for Physical Dependence and Addiction
TLDR
Phenibut is a potent psychoactive substance with GABAB agonist properties, which is emerging as a drug of misuse through growing internet sales and marketing as a “dietary supplement” is inaccurate and misleading.
Phenibut exposures and clinical effects reported to a regional poison center.
Five Unapproved Drugs Found in Cognitive Enhancement Supplements.
TLDR
Over-the-counter cognitive enhancement supplements may contain multiple unapproved drugs, and consumers could be exposed to up to four-fold greater than pharmaceutical dosages and as many as 4 un approved drugs when using individual products.
Acute behavioural disturbance associated with phenibut purchased via an internet supplier
TLDR
Altered mental status was the predominant manifestation of phenibut toxicity in these cases, prompting Clinicians to be aware of how phenIBut toxicity may present as the internet has widened access to such substances.
Prohibited Stimulants in Dietary Supplements After Enforcement Action by the US Food and Drug Administration
TLDR
There is tremendous variation in inpatient laboratory test and radiology test ordering among the house staff, an indicator of questionable or unnecessary care, and it is important to publish studies like this one to keep the conversation moving forward.
Analysis of Ingredients of Supplements in the National Institutes of Health Supplement Database Marketed as Containing a Novel Alternative to Anabolic Steroids
This case series analyzes whether supplements categorized as containing novel ingredients in the National Institutes of Health Dietary Supplement Label Database are accurately labeled.
Severe phenibut poisoning: An adolescent case cluster
Severe phenibut poisoning: An adolescent case cluster Katherine Z Isoardi , Sanjeewa Kulawickrama and Geoffrey K Isbister Queensland Poisons Information Centre, Queensland Children’s Hospital,
The FDA and Adulterated Supplements-Dereliction of Duty.
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