Quantitative variation in vascular endothelial growth factor mRNA expression during early flexor tendon healing: an investigation in a canine model

@article{Boyer2001QuantitativeVI,
  title={Quantitative variation in vascular endothelial growth factor mRNA expression during early flexor tendon healing: an investigation in a canine model},
  author={Martin I. Boyer and J Tracy Watson and Jue-ren Lou and Paul R. Manske and Richard H Gelberman and Shi-rong Cai},
  journal={Journal of Orthopaedic Research},
  year={2001},
  volume={19}
}
Vascular endothelial growth factor (VEGF) is a potent mediator of angiogenesis, with direct mitogenic activity on cells of endothelial origin. We quantified the temporal accumulation of VEGF mRNA at the repair site of an in vivo canine intrasynovial flexor tendon repair and rehabilitation model by means of quantitative Northern blot analysis, in order to detail a molecular signal involved in the intrinsic angiogenic process that accompanies early flexor tendon healing. Significant accumulation… 
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VEGF, VEGFR‐1, and CTGF cell densities in tendon are increased with cyclical loading: An in vivo tendinopathy model
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D dose-dependent vascular alterations from the delivery of an anti-angiogenic factor after tendon injury that can be detected through ultrasound imaging methods are demonstrated.
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