Quantitative variation in vascular endothelial growth factor mRNA expression during early flexor tendon healing: an investigation in a canine model

@article{Boyer2001QuantitativeVI,
  title={Quantitative variation in vascular endothelial growth factor mRNA expression during early flexor tendon healing: an investigation in a canine model},
  author={M. Boyer and J. Watson and J. Lou and P. Manske and R. Gelberman and S. Cai},
  journal={Journal of Orthopaedic Research},
  year={2001},
  volume={19}
}
  • M. Boyer, J. Watson, +3 authors S. Cai
  • Published 2001
  • Medicine, Biology
  • Journal of Orthopaedic Research
  • Vascular endothelial growth factor (VEGF) is a potent mediator of angiogenesis, with direct mitogenic activity on cells of endothelial origin. We quantified the temporal accumulation of VEGF mRNA at the repair site of an in vivo canine intrasynovial flexor tendon repair and rehabilitation model by means of quantitative Northern blot analysis, in order to detail a molecular signal involved in the intrinsic angiogenic process that accompanies early flexor tendon healing. Significant accumulation… CONTINUE READING
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    References

    SHOWING 1-10 OF 15 REFERENCES
    Fibroblast chemotaxis after tendon repair.
    • 97
    Flexor tendon repair
    • 216
    Vascular endothelial growth factor (VEGF) and its receptors
    • 3,370
    Vascular endothelial growth factor and its receptors.
    • 581
    The revascularization of healing flexor tendons in the digital sheath. A vascular injection study in dogs.
    • 110