Quantitative variation in cystic fibrosis-associated proteins in cystic fibrosis patients, carriers, and controls

@article{Jamieson1985QuantitativeVI,
  title={Quantitative variation in cystic fibrosis-associated proteins in cystic fibrosis patients, carriers, and controls},
  author={Alan Jamieson and Elizabeth Mackinlay and David A. Aitken and A. Cooke and M. A. Ferguson-Smith},
  journal={Human Genetics},
  year={1985},
  volume={70},
  pages={168-171}
}
Serum samples from patients with cystic fibrosis (CF), obligate heterozygotes, and normal controls have been examined by isoelectric focusing (IEF). Our results suggest that cystic fibrosis protein (CFP) is a normal serum protein exhibiting quantitative variation primarily dependent on possession of the CF allele. It is concluded that detection of CFP by IEF is an inappropriate screening test for the CF gene due to lack of specificity.