Quantitative transcription factor analysis of undifferentiated single human embryonic stem cells.

Abstract

BACKGROUND Human embryonic stem cells (hESCs) require expression of transcription factor genes POU5F1 (POU class 5 homeobox 1), NANOG (Nanog homeobox), and SOX2 [SRY (sex determining region Y)-box 2] to maintain their capacity for self-renewal and pluripotency. Because of the heterogeneous nature of cell populations, it is desirable to study the gene… (More)
DOI: 10.1373/clinchem.2009.131433

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