Quantitative trait locus detection using combined linkage/disequilibrium analysis.

  title={Quantitative trait locus detection using combined linkage/disequilibrium analysis.},
  author={Laura Almasy and Jeff T. Williams and Thomas D. Dyer and John Blangero},
  journal={Genetic epidemiology},
  volume={17 Suppl 1},
We describe an extension of the variance component linkage method that augments identity-by-descent information from relatives with identity-by-state information from unrelated individuals, exploiting disequilibrium to facilitate fine mapping of quantitative trait loci. An advantage of the combined linkage/disequilibrium test is that it detects association only in the presence of linkage and is not biased by population stratification. 

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