Quantitative trait locus analyses of sleep-times induced by sedative-hypnotics in LSXSS recombinant inbred strains of mice.

@article{Christensen1996QuantitativeTL,
  title={Quantitative trait locus analyses of sleep-times induced by sedative-hypnotics in LSXSS recombinant inbred strains of mice.},
  author={Steven C. Christensen and Thomas Johnson and P. D. Markel and Vanessa J. Clark and David W. Fulker and Robin P Corley and Allan C. Collins and Jeanne M. Wehner},
  journal={Alcoholism, clinical and experimental research},
  year={1996},
  volume={20 3},
  pages={543-50}
}
The long-sleep (LS) and short-sleep (SS) selected lines of mice show highly significant differences in sleep-time for many sedative-hypnotic drugs, and the quantitative genetic nature of these differences has been well-established. Using an interval-mapping approach, quantitative trait locus (QTL) analyses of LSXSS recombinant inbred (RI) strains have been applied to sleep-time responses for various classes of sedative-hypnotic drugs: alcohols (ethanol, n-propanol, and n-butanol), the atypical… CONTINUE READING

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