Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3).

@article{Ahn2009QuantitativeTL,
  title={Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3).},
  author={Jiyoung Ahn and Fredrick R. Schumacher and Sonja I. Berndt and Ruth M. Pfeiffer and Demetrius Albanes and Gerald L. Andriole and Eva Ardanaz and Heiner Boeing and Bas Bueno-de-Mesquita and Stephen J. Chanock and Françoise Clavel-Chapelon and W Ryan Diver and Heather Spencer Feigelson and J. Michael Gaziano and Edward L. Giovannucci and Christopher A. Haiman and Brian E. Henderson and Robert Nathaniel Hoover and Laurence N. Kolonel and Peter Kraft and Jing Ma and Lo{\"i}c Le Marchand and Kim Overvad and Domenico Palli and P{\"a}r Stattin and Meir J. Stampfer and Daniel O. Stram and Gilles Thomas and Michael J. Thun and Ruth C Travis and Dimitrios Trichopoulos and Jarmo Virtamo and Stephanie J Weinstein and Meredith Ann Yeager and Rudolf Kaaks and David J. Hunter and Richard B Hayes},
  journal={Human molecular genetics},
  year={2009},
  volume={18 19},
  pages={
          3749-57
        }
}
Twin studies suggest a heritable component to circulating sex steroid hormones and sex hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort Consortium, 874 SNPs in 37 candidate genes in the sex steroid hormone pathway were examined in relation to circulating levels of SHBG (N = 4720), testosterone (N = 4678), 3 alpha-androstanediol-glucuronide (N = 4767) and 17beta-estradiol (N = 2014) in Caucasian men. rs1799941 in SHBG is highly significantly associated with… CONTINUE READING

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