Quantitative trait loci on chromosomes 2p, 4p, and 13q influence bone mineral density of the forearm and hip in Mexican Americans.

@article{Kammerer2003QuantitativeTL,
  title={Quantitative trait loci on chromosomes 2p, 4p, and 13q influence bone mineral density of the forearm and hip in Mexican Americans.},
  author={Candace M. Kammerer and Jennifer L Schneider and S. A. Cole and James E. Hixson and Paul B. Samollow and Jeffrey R. O'Connell and R. Capillas Per{\'e}z and Thomas D. Dyer and Laura Almasy and John Blangero and Richard L. Bauer and Braxton D. Mitchell},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2003},
  volume={18 12},
  pages={2245-52}
}
UNLABELLED We performed a genome scan using BMD data of the forearm and hip on 664 individuals in 29 Mexican-American families. We obtained evidence for QTL on chromosome 4p, affecting forearm BMD overall, and on chromosomes 2p and 13q, affecting hip BMD in men. INTRODUCTION The San Antonio Family Osteoporosis Study (SAFOS) was designed to identify genes and environmental factors that influence bone mineral density (BMD) using data from large Mexican-American families. MATERIALS AND METHODS… CONTINUE READING

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A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

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