Quantitative trait loci mapped for TCF21 binding, chromatin accessibility and chromosomal looping in coronary artery smooth muscle cells reveal molecular mechanisms of coronary disease loci

@article{Zhao2020QuantitativeTL,
  title={Quantitative trait loci mapped for TCF21 binding, chromatin accessibility and chromosomal looping in coronary artery smooth muscle cells reveal molecular mechanisms of coronary disease loci},
  author={Q. Zhao and Michael Dacre and T. Nguyen and M. Pjanic and B. Liu and Dharini Iyer and P. Cheng and Robert C Wirka and Juyong Brian Kim and H. Fraser and T. Quertermous},
  journal={bioRxiv},
  year={2020}
}
  • Q. Zhao, Michael Dacre, +8 authors T. Quertermous
  • Published 2020
  • Biology
  • bioRxiv
  • Background To investigate the epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the functional regulation of chromatin structure and function, we have created a catalog of genetic variants associated with three stages of transcriptional cis-regulation in primary human coronary artery vascular smooth muscle cells (HCASMC). Results To this end, we have used a pooling approach with HCASMC lines to map regulatory variation that mediates binding of the CAD… CONTINUE READING

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