Quantitative trait loci for BMD in an SM/J by NZB/BlNJ intercross population and identification of Trps1 as a probable candidate gene.

@article{Ishimori2008QuantitativeTL,
  title={Quantitative trait loci for BMD in an SM/J by NZB/BlNJ intercross population and identification of Trps1 as a probable candidate gene.},
  author={Naoki Ishimori and Ioannis M. Stylianou and Ron Korstanje and Michael Marion and Renhua Li and Leah Rae B Donahue and Clifford J. Rosen and Wesley G. Beamer and Beverly J. Paigen and Gary A. Churchill},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2008},
  volume={23 9},
  pages={1529-37}
}
Identification of genes that regulate BMD will enhance our understanding of osteoporosis and could provide novel molecular targets for treatment or prevention. We generated a mouse intercross population and carried out a quantitative trait locus (QTL) analysis of 143 female and 124 male F(2) progeny from progenitor strains SM/J and NZB/BlNJ using whole body and vertebral areal BMD (aBMD) as measured by DXA. We found that both whole body and vertebral aBMD was affected by two loci on chromosome… CONTINUE READING
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