Quantitative tissue sodium concentration mapping of normal rat brain.

  title={Quantitative tissue sodium concentration mapping of normal rat brain.},
  author={J D Christensen and Bertrand Barrere and Fernando E. Boada and J M Vevea and Keith R. Thulborn},
  journal={Magnetic resonance in medicine},
  volume={36 1},
A quantitative in vivo method for obtaining maps of tissue sodium concentration (TSC) by MRI is compared to the invasive, global 22Na radionuclide dilutional technique in the normal rat brain. The MR method uses a three-dimensional projectional acquisition scheme to minimize signal losses from transverse relaxation. Internal calibration standards are used to convert the signal intensity into TSC after correction for B1 inhomogeneities by using the ratio of 23Na and 1H images obtained with… CONTINUE READING