Quantitative theory of hydrophobic effect as a driving force of protein structure.

Abstract

Various studies suggest that the hydrophobic effect plays a major role in driving the folding of proteins. In the past, however, it has been challenging to translate this understanding into a predictive, quantitative theory of how the full pattern of sequence hydrophobicity in a protein shapes functionally important features of its tertiary structure. Here… (More)
DOI: 10.1002/pro.2420

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