Quantitative targeted proteomics for understanding the blood-brain barrier: towards pharmacoproteomics.

  title={Quantitative targeted proteomics for understanding the blood-brain barrier: towards pharmacoproteomics.},
  author={Sumio Ohtsuki and Mio Hirayama and Shingo Ito and Yasuo Uchida and Masanori Tachikawa and Tetsuya Terasaki},
  journal={Expert review of proteomics},
  volume={11 3},
The blood-brain barrier (BBB) is formed by brain capillary endothelial cells linked together via complex tight junctions, and serves to prevent entry of drugs into the brain. Multiple transporters are expressed at the BBB, where they control exchange of materials between the circulating blood and brain interstitial fluid, thereby supporting and protecting the CNS. An understanding of the BBB is necessary for efficient development of CNS-acting drugs and to identify potential drug targets for… CONTINUE READING
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