Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: methodology, advantages, strategy, and prospects.

@article{Ohtsuki2011QuantitativeTA,
  title={Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: methodology, advantages, strategy, and prospects.},
  author={Sumio Ohtsuki and Yasuo Uchida and Yoshiyuki Kubo and Tetsuya Terasaki},
  journal={Journal of pharmaceutical sciences},
  year={2011},
  volume={100 9},
  pages={3547-59}
}
An understanding of the functional roles of proteins, for example, in drug absorption, distribution, metabolism, elimination, toxicity, and efficacy (ADMET/efficacy), is important for drug discovery and development. Equally, detailed information about protein expression is required. Recently, a new protein quantification method, called quantitative targeted absolute proteomics (QTAP), has been developed on the basis of separation and identification of protein digests by liquid chromatography… CONTINUE READING
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