Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states

  title={Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states},
  author={Nadine Ehmann and Sebastian van de Linde and Amit Alon and Dmitrij Ljaschenko and Xi Zhen Keung and Thorge Holm and Annika Rings and Aaron Diantonio and Stefan Hallermann and Uri Ashery and Manfred Heckmann and Markus Sauer and Robert J Kittel},
  booktitle={Nature communications},
The precise molecular architecture of synaptic active zones (AZs) gives rise to different structural and functional AZ states that fundamentally shape chemical neurotransmission. However, elucidating the nanoscopic protein arrangement at AZs is impeded by the diffraction-limited resolution of conventional light microscopy. Here we introduce new approaches to quantify endogenous protein organization at single-molecule resolution in situ with super-resolution imaging by direct stochastic optical… CONTINUE READING
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