Quantitative study of solid-state acid-base reactions between polymorphs of flufenamic acid and magnesium oxide using X-ray powder diffraction.

@article{Chen2010QuantitativeSO,
  title={Quantitative study of solid-state acid-base reactions between polymorphs of flufenamic acid and magnesium oxide using X-ray powder diffraction.},
  author={X. Chen and J. G. Stowell and K. R. Morris and S. Byrn},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2010},
  volume={51 4},
  pages={
          866-74
        }
}
  • X. Chen, J. G. Stowell, +1 author S. Byrn
  • Published 2010
  • Chemistry, Medicine
  • Journal of pharmaceutical and biomedical analysis
    • The purpose of this study is to investigate solid-state acid-base reactions between polymorphs of flufenamic acid (FFA) and magnesium oxide (MgO) using X-ray powder diffraction (XRPD). Polymorphs of FFA were blended with MgO and stored under conditions of 96.5% RH and 89% RH at 40 degrees C. The disappearance of FFA and production of magnesium flufenamate were monitored by XRPD. It was observed that the reactions between FFA and MgO proceeded following the Jander equation. Form I of FFA is more… CONTINUE READING
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