Quantitative study of solid-state acid-base reactions between polymorphs of flufenamic acid and magnesium oxide using X-ray powder diffraction.

@article{Chen2010QuantitativeSO,
  title={Quantitative study of solid-state acid-base reactions between polymorphs of flufenamic acid and magnesium oxide using X-ray powder diffraction.},
  author={X. Chen and J. G. Stowell and K. R. Morris and S. Byrn},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2010},
  volume={51 4},
  pages={
          866-74
        }
}
  • X. Chen, J. G. Stowell, +1 author S. Byrn
  • Published 2010
  • Chemistry, Medicine
  • Journal of pharmaceutical and biomedical analysis
  • The purpose of this study is to investigate solid-state acid-base reactions between polymorphs of flufenamic acid (FFA) and magnesium oxide (MgO) using X-ray powder diffraction (XRPD). Polymorphs of FFA were blended with MgO and stored under conditions of 96.5% RH and 89% RH at 40 degrees C. The disappearance of FFA and production of magnesium flufenamate were monitored by XRPD. It was observed that the reactions between FFA and MgO proceeded following the Jander equation. Form I of FFA is more… CONTINUE READING
    18 Citations
    Tetrathiafulvalene: A Gate to the Mechanochemical Mechanisms of Electron Transfer Reactions
    • 1
    • PDF
    Quantification of febuxostat polymorphs using powder X-ray diffraction technique.
    • 15
    In situ monitoring of pharmaceutical crystallisation
    • 1
    • PDF
    Advances in Solid-State Transformations of Coordination Bonds: From the Ball Mill to the Aging Chamber
    • 55
    • PDF
    An overview of recent studies on the analysis of pharmaceutical polymorphs.
    • 210
    Spray Drying of Cocrystals for Engineering Particle Properties : Diploma Work
    • 2
    • PDF

    References

    SHOWING 1-10 OF 27 REFERENCES
    Formation of physically stable amorphous phase of ibuprofen by solid state milling with kaolin.
    • S. Mallick, S. Pattnaik, +4 authors A. Mondal
    • Chemistry, Medicine
    • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
    • 2008
    • 94
    Polymorphic transformation of indomethacin under high pressures.
    • 53
    Hygroscopic stability and dissolution properties of spray-dried solid dispersions of furosemide with Eudragit.
    • 42