Quantitative studies of the mutagenesis of Toxoplasma gondii.

  title={Quantitative studies of the mutagenesis of Toxoplasma gondii.},
  author={Elmer R. Pfefferkorn and L C Pfefferkorn},
  journal={The Journal of parasitology},
  volume={65 3},
The induction of mutants resistant to 5-fluorodeoxyuridine (FUDR) was used to measure the efficiency of various physical and chemical mutagens on extracellular and intracellular Toxoplasma gondii. The frequency of resistant mutant was measured by plaque assay in human fibroblast cultures in the presence and absence of FUDR. When considered as a function of lethality, the most efficient mutagenesis was obtained with nitrosoguanidine treatment of extracellular parasites and with ethylmethane… CONTINUE READING
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