Quantitative structure-toxicity relationships using TOPS-MODE. 2. Neurotoxicity of a non-congeneric series of solvents.

@article{Estrada2001QuantitativeSR,
  title={Quantitative structure-toxicity relationships using TOPS-MODE. 2. Neurotoxicity of a non-congeneric series of solvents.},
  author={Ernesto Estrada and Enrique Molina and Eugenio Uriarte},
  journal={SAR and QSAR in environmental research},
  year={2001},
  volume={12 5},
  pages={445-59}
}
Neurotoxicities of a series of solvents in rats and mice have been modeled by means of the TOPS-MODE approach. Two quantitative structure-toxicity relationship (QSTR) models were obtained explaining more than 80% of the variance in the experimental values of neurotoxicity of 45 solvents. Only one compound was detected as statistical outlier for these models. In contrast, previous models explained less than 60% of the variance in this property for 44 solvents. Finally, the contributions to… CONTINUE READING

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