Quantitative structure-retention-pharmacokinetic relationship studies.

  title={Quantitative structure-retention-pharmacokinetic relationship studies.},
  author={Snezana Agatonovic-Kustrin and Joseph V. Turner and Beverley Dawn Glass},
  journal={Drug metabolism letters},
  volume={2 2},
Since the majority of lead compounds identified for drug clinical trials fail to reach the market due to poor efficacy in humans or poor pharmacokinetics (PKs), the prediction of PK properties in humans plays an important role in selection of potential drug candidates. The aim of the present study was to develop novel models for the prediction of separate PK parameters for a diverse set of drugs. Prediction would be based on the retention of each drug using micellar liquid chromatography (MLC… CONTINUE READING