Quantitative structure-property relationships for physiologically based pharmacokinetic modeling of volatile organic chemicals in rats.

@article{Bliveau2003QuantitativeSR,
  title={Quantitative structure-property relationships for physiologically based pharmacokinetic modeling of volatile organic chemicals in rats.},
  author={Martin B{\'e}liveau and Robert Tardif and Kannan Krishnan},
  journal={Toxicology and applied pharmacology},
  year={2003},
  volume={189 3},
  pages={221-32}
}
The objective of present study was to develop quantitative structure-property relationships (QSPRs) for the chemical-specific input parameters of rat physiologically based pharmacokinetic (PBPK) models (i.e., blood:air partition coefficient (P(b)), liver:air partition coefficient (P(l)), muscle:air partition coefficient (P(m)), fat:air partition coefficient (P(f)), and hepatic clearance (CL(h))), for simulating the inhalation pharmacokinetics of volatile organic chemicals (VOCs). The literature… CONTINUE READING

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