Quantitative structure-property relationship modeling of remote liposome loading of drugs.

  title={Quantitative structure-property relationship modeling of remote liposome loading of drugs.},
  author={Ahuva Cern and Alexander Golbraikh and Aleck Sedykh and Alexander Tropsha and Yechezkel Chezy Barenholz and Amiram Goldblum},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={160 2},
Remote loading of liposomes by trans-membrane gradients is used to achieve therapeutically efficacious intra-liposome concentrations of drugs. We have developed Quantitative Structure Property Relationship (QSPR) models of remote liposome loading for a data set including 60 drugs studied in 366 loading experiments internally or elsewhere. Both experimental conditions and computed chemical descriptors were employed as independent variables to predict the initial drug/lipid ratio (D/L) required… CONTINUE READING
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