Quantitative structure-activity relationships of antiarrhythmic drugs.

  title={Quantitative structure-activity relationships of antiarrhythmic drugs.},
  author={Satya Prakash Gupta},
  journal={Current pharmaceutical design},
  volume={4 6},
A Comprehensive review of quantitative structure-activity relationship (QSAR) studies on antiarrhythmic agents is presented. From the discussion point of view, the antiarrhythmic agents have been put into two broad classes: specific and nonspecific. While the main members of the former class can be beta-adrenergic blocking agents (beta-blockers), any chemical that can act directly on the myocardial cell membrane, producing a cardiodepressant effect via changes in basic electrophysiological… CONTINUE READING