Quantitative structure-activity relationship studies on anti-HIV-1 TIBO derivatives as inhibitors of viral reverse transcriptase.

Abstract

The anti-human-immunodeficiency-virus (HIV-1) activity of the derivatives of 4,5,6,7-tetrahydro-5-methylimidazo [4,5,1-jk] [1,4] benzodiazepin-2(1H)-one (TIBO) that have been found to elicit their action through the allosteric inhibition of the enzyme viral reverse transcriptase (VRT) is analysed in relation to the physicochemical properties of the molecules. Significant correlations are obtained between the activity and the hydrophobic constant and some dummy parameters of substituents. Based on these findings, the mechanism of action of these anti-HIV drugs is discussed.

Cite this paper

@article{Gupta1996QuantitativeSR, title={Quantitative structure-activity relationship studies on anti-HIV-1 TIBO derivatives as inhibitors of viral reverse transcriptase.}, author={Shilpa Gupta and Ravendra Garg}, journal={Journal of enzyme inhibition}, year={1996}, volume={11 1}, pages={23-32} }